<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40"><head><meta http-equiv=Content-Type content="text/html; charset=us-ascii"><meta name=Generator content="Microsoft Word 12 (filtered medium)"><style><!--/* Font Definitions */@font-face {font-family:SimSun; panose-1:2 1 6 0 3 1 1 1 1 1;}@font-face {font-family:SimSun; panose-1:2 1 6 0 3 1 1 1 1 1;}@font-face {font-family:Calibri; panose-1:2 15 5 2 2 2 4 3 2 4;}@font-face {font-family:"\@SimSun"; panose-1:0 0 0 0 0 0 0 0 0 0;}/* Style Definitions */p.MsoNormal, li.MsoNormal, div.MsoNormal {margin:0in; margin-bottom:.0001pt; font-size:11.0pt; font-family:"Calibri","sans-serif";}a:link, span.MsoHyperlink {mso-style-priority:99; color:blue; text-decoration:underline;}a:visited, span.MsoHyperlinkFollowed {mso-style-priority:99; color:purple; text-decoration:underline;}p.MsoListParagraph, li.MsoListParagraph, div.MsoListParagraph {mso-style-priority:34; margin-top:0in; margin-right:0in; margin-bottom:0in; margin-left:.5in; margin-bottom:.0001pt; font-size:12.0pt; font-family:"Times New Roman","serif";}p.MsoListParagraphCxSpFirst, li.MsoListParagraphCxSpFirst, div.MsoListParagraphCxSpFirst {mso-style-priority:34; mso-style-type:export-only; margin-top:0in; margin-right:0in; margin-bottom:0in; margin-left:.5in; margin-bottom:.0001pt; font-size:12.0pt; font-family:"Times New Roman","serif";}p.MsoListParagraphCxSpMiddle, li.MsoListParagraphCxSpMiddle, div.MsoListParagraphCxSpMiddle {mso-style-priority:34; mso-style-type:export-only; margin-top:0in; margin-right:0in; margin-bottom:0in; margin-left:.5in; margin-bottom:.0001pt; font-size:12.0pt; font-family:"Times New Roman","serif";}p.MsoListParagraphCxSpLast, li.MsoListParagraphCxSpLast, div.MsoListParagraphCxSpLast {mso-style-priority:34; mso-style-type:export-only; margin-top:0in; margin-right:0in; margin-bottom:0in; margin-left:.5in; margin-bottom:.0001pt; font-size:12.0pt; font-family:"Times New Roman","serif";}span.EmailStyle17 {mso-style-type:personal-compose; font-family:"Calibri","sans-serif"; color:windowtext;}.MsoChpDefault {mso-style-type:export-only;}@page WordSection1 {size:8.5in 11.0in; margin:1.0in 1.0in 1.0in 1.0in;}div.WordSection1 {page:WordSection1;}/* List Definitions */@list l0 {mso-list-id:340474618; mso-list-type:hybrid; mso-list-template-ids:-1316318636 67698689 67698691 67698693 67698689 67698691 67698693 67698689 67698691 67698693;}@list l0:level1 {mso-level-number-format:bullet; mso-level-text:\F0B7; mso-level-tab-stop:none; mso-level-number-position:left; text-indent:-.25in; font-family:Symbol;}@list l0:level2 {mso-level-number-format:bullet; mso-level-text:o; mso-level-tab-stop:none; mso-level-number-position:left; text-indent:-.25in; font-family:"Courier New";}@list l0:level3 {mso-level-tab-stop:1.5in; mso-level-number-position:left; text-indent:-.25in;}@list l0:level4 {mso-level-tab-stop:2.0in; mso-level-number-position:left; text-indent:-.25in;}@list l0:level5 {mso-level-tab-stop:2.5in; mso-level-number-position:left; text-indent:-.25in;}@list l0:level6 {mso-level-tab-stop:3.0in; mso-level-number-position:left; text-indent:-.25in;}@list l0:level7 {mso-level-tab-stop:3.5in; mso-level-number-position:left; text-indent:-.25in;}@list l0:level8 {mso-level-tab-stop:4.0in; mso-level-number-position:left; text-indent:-.25in;}@list l0:level9 {mso-level-tab-stop:4.5in; mso-level-number-position:left; text-indent:-.25in;}ol {margin-bottom:0in;}ul {margin-bottom:0in;}--></style><!--[if gte mso 9]><xml><o:shapedefaults v:ext="edit" spidmax="1026" /></xml><![endif]--><!--[if gte mso 9]><xml><o:shapelayout v:ext="edit"><o:idmap v:ext="edit" data="1" /></o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><br><br>Jeremy<br><br><div id="htc_header" style="">----- Forwarded message -----<br>From: "Stephens, Susan [JRDUS]" <sstephens1@ITS.JNJ.COM><br>Date: Wed, Apr 25, 2012 19:14<br>Subject: Intern Positions at Janssen Pharmaceutical R&D<br>To: "Stephens, Susan [JRDUS]" <sstephens1@ITS.JNJ.COM><br><br></div><div class=WordSection1><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'>The <i>In Silico</i> Immunology team in Janssen Pharmaceutical Research & Development L.L.C., a member of Johnson and Johnson's family of companies, is recruiting for two Research Scientists for 2012 Pharmaceutical R&D internships, located in Radnor, PA.<o:p></o:p></p><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'> <o:p></o:p></p><p class=MsoNormal>Please share information about the positions with any candidates that may be interested. Formal applications should be made on the J&J Career Web site (<a href="http://careers.jnj.com/" target="_blank"><span style='color:windowtext'>http://careers.jnj.com</span></a>).<br><br>Kind regards,<br><br>Susie<o:p></o:p></p><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'> <o:p></o:p></p><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><o:p> </o:p></p><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><b>2012 PHARMACEUTICAL R&D INTERNSHIPS in <i>In Silico</i> Immunology - </b><b>000004FN<o:p></o:p></b></p><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'> <o:p></o:p></p><p class=MsoNormal style='margin-bottom:6.0pt;text-align:justify;text-justify:inter-ideograph'><b>1. Network Pharmacology<o:p></o:p></b></p><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><span style='color:black'>Janssen Pharmaceutical Research & Development is seeking a graduate student with strong computational skills interested in an internship position in the Network Pharmacology group. The candidate’s current research area should be Systems Biology, Bioinformatics, Computer Science or Engineering, have a solid understanding of network analysis methods and biology as well as programming experience and ability to write R, Matlab and/or Perl script. Experience with large-scale genomics data and a solid understanding of bioinformatics tools and databases is a plus. The successful candidate will focus on the development of bioinformatics approaches to integrate and analyze data from various cutting-edge projects in the Immunology Therapeutic Area. <o:p></o:p></span></p><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><o:p> </o:p></p><p class=MsoNormal style='margin-bottom:6.0pt;text-align:justify;text-justify:inter-ideograph'>The candidate will develop and investigate methods to understand dysregulated mechanisms in disease using Network Pharmacology approaches. They will conduct network analysis and inference on large-scale data that provides a global view of the disease that would help determining its representation in the relevant in-vivo and in-vitro models. <o:p></o:p></p><p class=MsoListParagraphCxSpFirst style='margin-bottom:6.0pt;text-align:justify;text-justify:inter-ideograph;text-indent:-.25in;mso-list:l0 level1 lfo1'><![if !supportLists]><span style='font-size:11.0pt;font-family:Symbol'><span style='mso-list:Ignore'>·<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='font-size:11.0pt;font-family:"Calibri","sans-serif"'>Construct biological networks from molecular profiling data and from molecular interaction data stored in databases<o:p></o:p></span></p><p class=MsoListParagraphCxSpMiddle style='margin-bottom:6.0pt;text-align:justify;text-justify:inter-ideograph;text-indent:-.25in;mso-list:l0 level1 lfo1'><![if !supportLists]><span style='font-size:11.0pt;font-family:Symbol'><span style='mso-list:Ignore'>·<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='font-size:11.0pt;font-family:"Calibri","sans-serif"'>Conduct research on topological analysis to find key regulatory genes/proteins via biological network and genomic data <o:p></o:p></span></p><p class=MsoListParagraphCxSpMiddle style='margin-bottom:6.0pt;text-align:justify;text-justify:inter-ideograph;text-indent:-.25in;mso-list:l0 level1 lfo1'><![if !supportLists]><span style='font-size:11.0pt;font-family:Symbol'><span style='mso-list:Ignore'>·<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='font-size:11.0pt;font-family:"Calibri","sans-serif"'>Identify robust sub-networks using different data modalities (mRNA, proteins, DNA, etc.)<o:p></o:p></span></p><p class=MsoListParagraphCxSpLast style='margin-bottom:6.0pt;text-align:justify;text-justify:inter-ideograph;text-indent:-.25in;mso-list:l0 level1 lfo1'><![if !supportLists]><span style='font-size:11.0pt;font-family:Symbol'><span style='mso-list:Ignore'>·<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='font-size:11.0pt;font-family:"Calibri","sans-serif"'>Reconstruct network modules from the identified key regulators to discover affected biological processes and disease-related genes<o:p></o:p></span></p><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'> <o:p></o:p></p><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><b>2. Lifecycle Management <o:p></o:p></b></p><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><o:p> </o:p></p><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><span style='color:black'>Janssen Pharmaceutical Research & Development is seeking a graduate student with strong computational skills interested in an internship position in focused on Lifecycle Management. The candidate’s current research area should be Systems Biology, Bioinformatics, Computer Science or Engineering. </span>The intern will be responsible for developing algorithms and workflows that will facilitate the analysis of preclinical and clinical data. Through the implementation of these workflows, the intern will explore potential new disease indications for marketed and late stage development clinical compounds across the large and small molecule Immunology Therapeutic Area portfolio. The successful intern will work with the <i>In Silico</i> Immunology team to develop computational methodologies that will enable the combination of data outputs from different software platforms to build <i>in silico</i> networks of autoimmune and pulmonary diseases. <o:p></o:p></p><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><o:p> </o:p></p><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'>Experience in computational algorithms and mathematical modeling, preferably of biological or disease networks, is required for this position. Analysis of large datasets, especially microarray data, is preferred. Expertise in computer software such as R, Matlab, Ingenuity Pathways, and Cytoscape is also desirable.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p></div></body></html>